Shifting from the single to the multitarget paradigm in drug discovery
نویسندگان
چکیده
منابع مشابه
Shifting from the single to the multitarget paradigm in drug discovery.
Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach. In this article, we review and discuss the concepts of drug repurposing, polypharmacology, chemogenomics, phenotypic screening and high-throughput in vivo testing of mixture-based libraries in...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2013
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2013.01.008